In the mid-1990s, University of Cambridge biochemists David Klenerman and Shankar Balasubramanian were trying to solve a fundamental problem: how to watch a single DNA polymerase molecule at work. Their approach used modified nucleotides, called reversible terminators, tagged with four different colors of fluorescent molecules. If one of these “terminators” was grabbed by the DNA polymerase and incorporated onto the replicating DNA strand, it would block the addition of any other bases until removed using a separate chemical reaction.
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Европа боится, что президент США Дональд Трамп и его администрация забудут о России и украинском конфликте из-за боевых действий против Ирана. Об этом в беседе с «Лентой.ру» рассказал британский политолог, президент Проекта «США — Ближний Восток» Даниэль Леви.，更多细节参见体育直播
The intuition behind this mechanism is best illustrated by Wason’s (\citeyearwason_failure_1960) rule discovery task. When asked to discover a hidden rule governing number triples (e.g., 2-4-6), participants overwhelmingly proposed triples that fit their current hypothesis (e.g., testing 8-10-12 to confirm “increasing even numbers”) rather than triples that would defy it. Because the true rule was simply “increasing numbers,” these positive tests appeared to confirm people’s more restrictive hypotheses.